E-Book

E-Book 3rd Congress

  • Unraveling the Regulatory Role of microRNAs and Long Non-coding RNAs in Peripheral Blood Mononuclear Cells of Autoimmune Diseases
  • Hadis Rahimi,1 Shadi Nazarifard,2 Gholamreza Shahsavari,3,*
    1. Student research committee, Lorestan University of Medical Sciences, Khorramabad, Iran
    2. Student research committee, Lorestan University of Medical Sciences, Khorramabad, Iran
    3. Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


  • Introduction: Introduction: Autoimmune diseases represent a diverse group of conditions marked by immune system dysregulation. PBMCs, pivotal in immune surveillance, offer valuable insights into the molecular landscape of autoimmune disorders. This section provides an overview of autoimmune diseases, emphasizing the significance of studying PBMCs and the emerging roles of miRNAs and lncRNAs in immune regulation.
  • Methods: Methods: The systematic review employed a comprehensive literature search strategy, targeting articles in PubMed, Scopus, and Web of Science. Selection criteria favored studies elucidating miRNA and lncRNA expression in PBMCs of autoimmune diseases, employing robust methodologies. Data extraction, synthesis, and critical analysis were performed to organize findings and identify research gaps.
  • Results: MicroRNA Regulation in Autoimmune Diseases: This section focuses on miRNA expression profiles in PBMCs associated with specific autoimmune diseases. For instance, the overexpression of miR-146a and miR-155 in Sjögren's syndrome and primary Sjögren's syndrome, respectively, suggests their potential as disease-specific biomarkers. The dysregulation of miR-146a in rheumatoid arthritis PBMCs indicates its role in the pathogenesis. 4. Long Non-coding RNAs in Autoimmune Disorders: The role of lncRNAs in autoimmune diseases is explored, highlighting their involvement in immune cell activation and signaling pathways within PBMCs. Elevated expression of lncRNA IFNG-AS1 in rheumatoid arthritis patients suggests its regulatory impact on inflammatory responses. The upregulation of LOC100652951 and LOC100506036 in T cells of rheumatoid arthritis patients underscores their potential as biomarkers. 5. Integrative Analysis and Future Directions: An integrative analysis synthesizes findings, emphasizing the interconnected regulatory networks orchestrated by miRNAs and lncRNAs in PBMCs. Research gaps, limitations, and future directions in the field are critically discussed, guiding subsequent investigations.
  • Conclusion: Conclusion: This comprehensive review provides a nuanced understanding of the regulatory roles of miRNAs and lncRNAs in PBMCs of autoimmune diseases. Insights gleaned from these molecular interactions hold promise for advancing diagnostic approaches and therapeutic interventions in the realm of autoimmune disorders.
  • Keywords: microRNA, Autoimmune Diseases, Mononuclear Cells