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E-Book 3rd Congress

  • The importance of EGFR (rs712829) gene polymorphism as a predictive marker for risk of lung cancer in Iranian population
  • Milad Pezeshki,1 Mahdi Nakhaee,2 Jamshid Ansari,3,* Azam Ahmadi,4 Saeed Ziaei,5 Roja Valipoor,6
    1. Development and research group of Lifeandme Company, Tehran, Iran.
    2. Development and research group of Lifeandme Company, Tehran, Iran.
    3. Department of Oncology, Ayatollah Khansari Hospital, Arak university of Medical Sciences, Arak, Iran.
    4. Infectious Diseases Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran.
    5. Director of development and research group of Lifeandme Company, Tehran, Iran.
    6. Department of Laboratory Medicine, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


  • Introduction: Lung cancer is the leading cause of cancer death globally. In Iran lung cancer is the third most common type of cancer and its prevalence is increasing rapidly. The epidermal growth factor receptor (EGFR) plays an important role in cell proliferation and signaling. The existence of rs712829 polymorphism in the EGFR gene can induce the carcinogenic process in the lung. In this study, we examined the association between EGFR (rs712829) gene polymorphism and lung cancer risk among the Iranian population.
  • Methods: A total of 200 patients with primary lung cancer at Ayatollah Khansari Hospital, Arak, and 200 matched healthy controls were recruited into this study. EGFR rs712829 single nucleotide polymorphism (SNP) was genotyped by PCR-RFLP techniques for this association with lung cancer risk. Finally, statistical analysis was done using the software SPSS version 16. Binary logistic regression analysis was performed to evaluate the association of polymorphism studied with the risk of lung cancer.
  • Results: A significant association was observed between the GG genotype (P= 0.039, OR= 5.500, CI=95%; 1.710- 11.921) and also G (P= 0.001, OR= 2.967, CI=95%; 1.557- 5.691) allele of rs712829 SNP with lung cancer risk, this was while the TT genotype and T allele of this polymorphism showed a protective role against risk of lung cancer.
  • Conclusion: In conclusion, EGFR rs712829 was associated with a risk of lung cancer. The rs712829 polymorphism can be used as a predictive marker for the risk of lung cancer in the Iranian population, but more studies are required to confirm the present findings.
  • Keywords: Predictive marker, Lung cancer, Single nucleotide polymorphism, rs712829, EGFR gene.