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E-Book 3rd Congress

  • Cell membrane camouflaged nanoparticles for drug delivery
  • Amirhossein Salati,1,* Kamand Karimi Taheri,2 Melika Eslamian Dehkordi,3 Issa Layali,4
    1. Bachelor’s student, Microbiology group, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
    2. Bachelor’s student, Microbiology group, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
    3. Bachelor’s student, Microbiology group, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
    4. Department of Biochemistry and Biophysics, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.


  • Introduction: Nanoparticles can accumulate at action sites, such as tumors, when coated. This represents a significant advancement in improving therapeutic indicators. Coated nanoparticles are a new category of nano biomimetic drugs. They have the flexibility of artificial nanoparticles. They also have the unique characteristics of cell membranes. Drugs prepared by traditional methods have two negative properties. They include side effects, non-specific toxicity, and the need for high doses. High doses are necessary for effectiveness. However, combination drugs based on nanoparticle coating technology have preferred accumulation properties. They also have unique physical and chemical properties. They have better drug release and increased drug encapsulation. Furthermore, nanodrugs can regulate themselves in larger dimensions. They can also produce themselves in these dimensions. Nanomedicine aims to make therapeutic nanofibers circulate in the body for a long time. This helps transfer them effectively and increases their therapeutic and clinical efficiency. Typically, researchers use polyethylene glycol (PEG) to stabilize nanoparticles and prevent opsonization. However, recent research shows that the immune system reacts to anti-PEG. In response, scientists have turned to another approach. They have turned to red blood cells (RBC). RBCs play a role in long-distance transportation in the human body. The process of preparing nanoparticles along with the RBC membrane involves two steps. First, we place RBCs in a hypotonic environment to remove their internal components. Then, a permeable membrane extrudes them to synthesize RBC-NPs. Mechanical extrusion combines the vesicles with polymeric PLGA nanoparticles. RBC-NPs have a much longer half-life compared to PEG. They also exhibit immune-compatible systemic properties. Additionally, this method allows for the modification of nanoparticles with ligands. Amino, hydroxyl, and sulfhydryl groups form the basis of the ligands. We can use conjugation techniques and targeted ligands to modify the nanoparticles. The cell's intrinsic homotypic and heterotypic membranes have adhesive properties. In addition to targeted ligands. You can use these to prevent extra synthesis stages.
  • Methods: This article uses an extensive search of PubMed - NCBI and Google Scholar databases - and the study of almost 30 articles and analysis of the studies done in the last ten years on this issue has been done.
  • Results: Coated nanoparticles consist of natural and artificial components. They can use the natural component for biochemical methods. A cell membrane supports it. This can affect drug delivery. It can be very difficult or even impossible to achieve with traditional methods. The artificial component has nanoparticles and an artificial core. Doctors can use multiple drugs for drug delivery and produce preferential effects. Furthermore, you can adjust the artificial core to possess specific properties. This results in greater effectiveness and efficiency.
  • Conclusion: Bio-mimetic nanoparticles have a very high therapeutic potential. They incorporate the characteristics of both natural and artificial platforms. In general, the outlook for combination drug delivery is very promising. Coated nanoparticles form the basis. It could treat many diseases.
  • Keywords: Nanoparticles/RBC/PLGA/Nano/Nanomedicine