E-Book

E-Book 3rd Congress

  • Long Noncoding RNAs: Emerging Biomarkers in Atherosclerosis - A Comprehensive Review
  • Gholamreza Shahsavari,1,* Fatemeh Ahmadpour,2 Asma Sepahdar,3
    1. Department of Clinical Biochemistry, Lorestan University of Medical Sciences, Khorramabad, Iran
    2. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
    3. Razi Herbal Medicines Research Center Lorestan University of Medical Sciences


  • Introduction: Atherosclerosis, a chronic inflammatory disorder, stands at the forefront of cardiovascular diseases, posing a substantial global health burden. The intricate interplay of various cellular processes orchestrates the progression of atherosclerosis, necessitating a nuanced understanding of its molecular underpinnings. In recent years, Long Non-Coding RNAs (lncRNAs) have emerged as crucial regulators in diverse biological pathways, including those intricately linked to atherosclerosis.
  • Methods: Literature Search: Rigorous searches across PubMed, Scopus, and Web of Science databases (up to January 2023) were conducted, employing keywords related to atherosclerosis and lncRNAs. Inclusion Criteria: Studies specifically exploring the nexus between lncRNAs and atherosclerosis were included. Exclusion Criteria: Non-English literature, reviews, and studies tangential to lncRNAs in atherosclerosis were excluded.
  • Results: MALAT1: Regulates NF-κB signaling via interaction with miR-330-5p, contributing to atherosclerosis. HCG11: Upregulated in cerebral atherosclerosis, showing promise as a biomarker for cerebrovascular events. TUG1: Silencing attenuates atherosclerosis-induced myocardial injury through miR-30b-3p and Brd4 regulation. APPAT: Suppresses smooth muscle cell proliferation and migration via interaction with miR-647 and FGF5. BANCR: Induces vascular smooth muscle cell proliferation by downregulating miR-34c methylation. ZFAS1: Regulates inflammatory responses and cholesterol efflux via the miR-654-3p-ADAM10/RAB22A axis. TCONS_00034812: Upregulated in atherosclerosis, upregulates miR-21 through methylation in vascular smooth muscle cells. SOX2-OT: Upregulated in carotid atherosclerosis, potential predictive indicator
  • Conclusion: This systematic review provides a comprehensive insight into lncRNAs associated with atherosclerosis, showcasing their potential as biomarkers. Validation in larger studies is pivotal for clinical translation.
  • Keywords: Atherosclerosis, Long non-coding RNA, lncRNA, Biomarkers, Diagnosis, Cardiovascular disease, Systema