E-Book

E-Book 3rd Congress

  • Exosomal miRNAs: Emerging Biomarkers for Cervical Cancer Diagnosis, Prognosis, and Therapy
  • Amirsoheil Karami,1,*
    1. Bachelor’s student, Microbiology group, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.


  • Introduction: Exosomes, minuscule extracellular bodies released by a diverse range of cells, including neoplastic cells, exhibit an intricate composition of molecules. These vesicles encapsulate miRNAs, which are small non-coding RNA molecules instrumental in regulating gene expression. Evidence has consistently shown miRNAs to modulate a plethora of cellular processes, including carcinogenesis and tumor progression.
  • Methods: To comprehensively understand the role of miRNAs in cervical cancer, we conducted a rigorous literature search utilizing PubMed, Google Scholar, and NCBI databases. This search yielded 36 pertinent articles, which were meticulously reviewed and analyzed to provide a deeper understanding of this topic.
  • Results: The association of exosomal miRNAs with cervical cancer progression has been demonstrated in various studies. One study observed lower levels of miR-1228-5p, miR-33a-5p, miR-3200-3p, and miR-6815-5p in the plasma of cervical cancer patients compared to healthy controls. These miRNAs are involved in cellular processes crucial for cancer development, encompassing cell proliferation, invasion, and metastasis. Another study revealed elevated levels of miR-605-5p, miR-6791-5p, miR-6780a-5p, and miR-6826-5p in the plasma of cervical cancer patients compared to healthy controls. These miRNAs are also engaged in processes essential for cancer development, including angiogenesis and immune evasion. These findings suggest that exosomal miRNAs hold promise as clinical markers for cervical cancer. Biomarkers are biological entities employed to diagnose, monitor, or predict the trajectory of a disease. Exosomal miRNAs are a promising biomarker for cervical cancer due to their relative ease of measurement and their ability to be detected in blood, a non-invasive sample. In addition to their potential as biomarkers, exosomal miRNAs could also be utilized to develop novel diagnostic tests for cervical cancer. These tests could be employed to screen for cervical cancer in women at high risk for the disease, such as those infected with human papillomavirus (HPV). Moreover, exosomal miRNAs are being investigated as potential therapeutic targets for cervical cancer. One study demonstrated that inhibiting the production of miR-146a-3p, which is elevated in cervical cancer, could induce cancer cell death.
  • Conclusion: The burgeoning diagnostic potential of exosomal microRNAs (miRNAs) in cervical cancer is garnering widespread attention. These non-invasive biomarkers hold immense promise for early-stage detection, personalized treatment, and long-term disease monitoring. To fully harness the transformative power of exosomal miRNAs, ongoing research is imperative to address the remaining challenges and optimize their integration into existing cervical cancer screening and treatment protocols. As exosomal miRNA profiling matures, its widespread adoption is anticipated to revolutionize cervical cancer management, leading to improved patient outcomes and a reduction in mortality rates.
  • Keywords: miRNA, Cervical Cancer, Exosome