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  • the role of probiotics in the treatment of colorectal cancer before and after surgery review article
  • Haniye Fayezi,1,*
    1. M.sc student of Pathogenic Microbes Islamic Azad University North Tehran Branch


  • Introduction: Colorectal cancer is a common and devastating disease that affects millions of people around the world. Colorectal cancer develops in the colon or rectum. It usually begins as small, non-cancerous polyps that gradually turn into cancerous masses. Colorectal cancer risk factors include age, family history, some genetic conditions and lifestyle factors such as diet and physical activity. Research shows that probiotics may have a positive effect on colorectal cancer patients by modulating the gut microbiota and enhancing immune system response. These effects could potentially inhibit tumor growth and improve treatment results. Administration of probiotics before surgery in patients who undergo gastrointestinal surgery can reduce postoperative infectious complications.
  • Methods: Inclusion criteria included studies of patients with CRC who underwent chemotherapy, radiotherapy, open, laparoscopic or robotic surgery for colorectal cancer with curative intent. Studies included randomized controlled trials with a comparator group, a control group, or a placebo group. Primary outcomes included reduction in duration, severity, and incidence of antibiotic-associated diarrhea, chemotherapy-associated diarrhea, and especially probiotic-associated infection.
  • Results: The findings suggest that probiotics are very important for the prevention and treatment of CRC. The intervention of probiotic bacteria during surgery can prevent postoperative complications in patients with colorectal cancer and reduce the overall infection rate after surgery and can be a valuable adjunctive treatment in colorectal cancer surgery. The effectiveness should be confirmed by more clinical trials in the future and the most valuable ways to prevent CRC should be investigated. When aggressive tumors form, probiotics can cooperate with surgery and chemotherapy to treat them, reduce the complications associated with surgery and chemotherapy, improve the effectiveness of chemotherapy and improve the quality of life of patients. Some studies suggest that probiotics may prevent CRC metastasis.
  • Conclusion: The use of probiotics to prevent CRC surgical inflammation is promising. It was found that the combination of more than one microorganism, such as Lactobacillus and Bifidobacterium, improves treatment and improves surgery. A systematic review and meta-analysis of studies show that preoperative probiotic administration may have an effect in reducing postoperative complications, including general infectious complications, in patients undergoing colorectal cancer surgery without any significant side effects. Therefore, probiotics may be considered a useful adjunct to routine care after colorectal cancer surgery. The administration of probiotics in patients with CRC not only reduces the risk of postoperative infection, but also reduces the tumor incidence in the long term and also improves the general quality of life. Considering the diversity in the use and types of probiotics, more research is necessary to create an optimal treatment protocol.
  • Keywords: Colorectal Cancer, Probiotics, Gastrointestinal, Microbiota