E-Book

E-Book 3rd Congress

  • Urinary Exosomes; Innovative insight into diagnosis and treatment of renal diseases
  • Banafsheh Yalameha,1 Reza Rahbarghazi,2,*
    1. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
    2. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran


  • Introduction: Exosomes, endosomal-based nano-sized vesicles, are involved in cell-to-cell intercommunication. Exosomes are produced under physiological and pathological conditions with prominent distribution in biofluids. In the urinary system, urinary exosomes (UEs), with an average diameter of 20-100 nm, are excreted by renal tubules epithelial cells, glomerular podocytes, and epithelial cells of the genitourinary tract (bladder and prostate). These exosomes harbor several signaling biomarkers, including membrane proteins, transcription factors, and microRNAs. UEs serve as immune effectors for the protection of the urinary tract against bacterial infection via carrying multiple innate immune proteins.
  • Methods: In this study, several sources were searched in numerous databases including PubMed/Medline, Scopus, and Google Scholar using keywords including; exosomes, urinary exosomes, biomarker, renal diseases, etc.
  • Results: Recent findings have confirmed the potential diagnostic properties of UEs in different abnormalities, such as renal tissue injuries. It is thought that rapid and accurate urine assay in terms of UE biomarkers may facilitate non-invasive diagnosis and develop prosperous management programs for patients suffering from kidney disorders. Besides, changes in the UE molecular signature can help us in the comprehension of the various renal diseases. The molecular composition of UEs displays their cellular origin, making them a promising source of biomarkers for kidney dysfunction and structural damage.
  • Conclusion: Despite recent progress in the detection of patient-specific UE proteome and transcriptome, UE research is still in its infancy, and multi-omics analysis is becoming an increasingly important area of study. The combination of exosomes and multi-omics analysis may provide an in-depth understanding of cellular changes and the essence of disease.
  • Keywords: Urine; Exosomes; Biomarkers; Kidney Disease; Diagnostic