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E-Book 3rd Congress

  • Biology of blood and brain transplantation review article
  • kosar reihanpour baghkhoshki,1,*
    1. Bachelor student of Microbiology Islamic Azad University Sirjan Sirjan, Kerman, Iran


  • Introduction: The primary process of plasma membrane invagination results in the formation of an early sorting endosome, a saucer-shaped structure that contains absorbed proteins and genetic elements from the cytoplasm as well as cell membrane proteins. After secondary fusing of the endosomal limiting membrane, early sorting endosomes develop into late sorting endosomes, which finally arrive in MVBs. In this opinion, we present a platform of neuroimmune organoids created from induced pluripotent stem cells to identify the variety of human cell-based brain TRM models and investigate their functions in tissue homeostasis and illness.
  • Methods: After being planted in culture plates, the MSC cell line was split into two groups based on whether BDNF was present or not. The BMExos group consisted of culture plates with a BDNF protein solution, while the MExos group consisted of culture plates without a BDNF solution. Data were gathered on a particular form and combined regarding the mode of administration, medication monitoring, risk factors unique to seizures, neurological diseases linked to seizures, prophylaxis against seizures, and the incidence of seizures.
  • Results: When BDNF was added to the culture media, the shape and development of MSCs remained mostly unchanged. Analysis was done on the extraction ratio between BMExos and MExos. In accordance with local policies, prophylaxis of seizures was administered to all patients. Due to graft rejection, death, and financial constraints on traveling to finish testing, sixteen were left unfinished. Out of the 13 recipients, 11 finished their pre- and post-HCT imaging studies.
  • Conclusion: The 3D-CC-BMExos scaffolds’ high porosity ratio and exceptional biocompatibility may offer a favorable milieu for both in vitro and in vivo cell proliferation and differentiation. In summary, 3D-CC-BMExos therapy has been shown to improve neuronal regeneration following traumatic brain injury (TBI) and has the potential to be used in clinical settings in the future. Utilizing state-of-the-art molecular technologies to study the impact of lifestyle and systemic interventions has provided understanding of the cellular and molecular targets as well as the origin tissues of pro-youthful and pro-aging factors found in blood.
  • Keywords: traumatic brain injury ,Neurodegenerative diseases, BDNF,Seizures ,Prophylaxis