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E-Book 3rd Congress

  • Serological Investigation of Toxoplasmosis in Pregnant Women with Preeclampsia
  • Saeed Radin,1 Samaneh Abolbashari,2 Vida Vakili,3 Asieh Maleki Abardeh,4 Aida Gholoobi,5,*
    1. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences
    2. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    3. Department of Family Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    4. Department of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran.
    5. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


  • Introduction: Considering the importance of preeclampsia and the high prevalence of Toxoplasma gondii infection and the need for more studies mentioned in various articles, the present study was conducted to investigate Toxoplasma gondii serum antibodies in pregnant women with and without preeclampsia.
  • Methods: This cross-sectional study was conducted in 1400 at Bu Ali Research Institute. Blood samples collected in the study approved by the university with code 970385 were used. Preeclampsia was diagnosed based on its diagnostic criteria according to the American College of Obstetricians and Gynecologists (ACOG) guidelines. Patients' serum samples were checked for the presence of IgM and IgG antibodies against Toxoplasma gondii by ELISA method. Finally, the obtained data were entered into SPSS statistical software and compared between the two groups.
  • Results: A total of 136 pregnant women with an average age of 32.90 ± 7.12 years including 72 patients with preeclampsia and 64 women without preeclampsia signs and symptoms were included. In the preeclamptic group, 9 women (12/5%), and in the non-preeclamptic group 6 women (9/4%) were positive for Toxoplasma gondii IgG antibody. The difference in Toxoplasma gondii antibody positivity in the two groups was not statistically significant. (Chi-square test; p=0/561). Also, there was no significant difference between patients with and without Toxoplasma gondii in terms of age (p=0/099), level of education (p=0/075), and gravid status (p=0/641). But, there was a significant difference in terms of pre-pregnancy weight (p=0/043).
  • Conclusion: The results obtained in the present study showed that positivity in terms of Toxoplasma gondii IgG antibody has no significant relationship with the development of preeclampsia. Further studies are needed to further investigate this issue, focusing on the relationship of recent Toxoplasma gondii infections with the development of preeclampsia.
  • Keywords: preeclampsia, Toxoplasma gondii, pregnancy