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E-Book 3rd Congress

  • Investigating the effect of benign neutropenia in Arabian residents of Mashhad on obesity: The role of MPO in this process
  • akram aminian,1 hadi mohebalian,2,* Farzane Bonyadi,3 Samin Madrasah,4
    1. Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
    2. Department of Immunology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
    3. Department of Basic science, Histology section, Faculty of Veterinary medicine, Urmia University, Urmia, Iran
    4. Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran


  • Introduction: Benign neutropenia is a disease that has the ability to become an inflammatory condition . Clinically, it is defined as a neutrophil count of less than 2000/Μl . In obesity, neutrophils with an active phenotype produce myeloperoxidase (MPO). This enzyme increases the adipogenesis pathway by activating inflammation. In this study, the prevalence of benign neutropenia was investigated in Arab residents of Mashhad. A total of 70 healthy Arab residents (male/female) from Mashhad city in Iran were studied. A blood sample was taken and analyzed for the presence of ethnically benign neutropenia. The results of this study showed that the prevalence of ethnically benign neutropenia was 9.28% (9/70) in Arab residents. Therefore, in people suffering from benign neutropenia and obesity at the same time, Defective cycle caused by MPO, facilitates the process of obesity.
  • Methods: Totally 70 Arabian healthy residents (male/female) from Mashhad city in Iran were studied. they were asked for their familial background of these diseases. The data were expressed as the Mean±SE (Standard Error Mean). Student t-test was used for analysis. Statistical analysis was done using Prism version 6.07 software. P-values less than 0.05 were considered significant.
  • Results: Results showed that prevalence of benign ethnic neutropenia in Arabian residents was 9.28% (70/9). Differential hematologic aspect of each group was determined. There is a significant decrease in number of neutrophils and also in their differential count in patients than health peoples.
  • Conclusion: According to past studies the increasing amount of MPO in patients suffering from neutropenia should be considered. The co-occurrence of obesity and neutropenia is an important issue in future studies .Because of the MPO communication link between these two pathological conditions
  • Keywords: MPO, neutropenia, obesity, inflammation