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E-Book 3rd Congress

  • The Role Of Probiotics In The Treatment of Bacterial Infections of The Genital Tract In Women Review Article
  • Mahdiyeh Nikdel,1 Haniye Fayezi,2,*
    1. B.sc student of Microbiology Islamic Azad University East Tehran Branch
    2. M.sc student of Pathogenic Microbes Islamic Azad University North Tehran Branch


  • Introduction: Urinary infections are the most common bacterial infections seen in society, especially among women, and affect their daily lives. Urinary tract infections in women usually begin with vaginal infections and progress towards the urethra and bladder. Probiotic interventions are partly effective in the treatment and Prevention of genital infections. These infections can cause discomfort, burning urine, itching, and abnormal discharge. Quick treatment of these infections is crucial to prevent complications. Products containing Lactobacillus species can prevent frequent urinary tract infections. Escherichia coli is the main pathogen involved in urinary tract infections that spread from the anus to the vagina and then rise above the sterile urinary tract, thereby affecting the urinary tract. Probiotics do not cause antibiotic resistance and may have other health benefits due to vaginal recolonization with lactobacilli. However, more comprehensive research is needed to recommend probiotics as an alternative to antibiotics.
  • Methods: Probiotics are living microorganisms that are useful to the host when consumed in sufficient quantities. When it comes to genital bacterial infections, probiotics can help fight harmful bacteria and support the growth of beneficial bacteria. While probiotics can play a beneficial role in the management of genital bacterial infections, they should be used along with other therapies recommended by healthcare professionals. This may include antibiotics or other medications based on the type of infection. In a review of 9 clinical trials with a total of 726 patients, different strains of Lactobacillus (orally or suppositories) were used and showed different effectiveness in preventing recurrent urinary tract infections.
  • Results: In recent years, several clinical trials have been conducted to investigate whether specific lactobacilli( oral or intra-vaginal ) species combined with antibiotics can be effective in treating or preventing vaginal infections.Antibiotics kill pathogenic agents while Lactobacillus GR - 1 and RC-14 inhibit the growth and adhesion of pathogens of the genitourinary tract, reduce vaginal inflammation and strengthen immune defenses, all of which can make the combined treatment of probiotics with antibiotics more effective. Studies have shown that probiotics can help prevent and treat genital bacterial infections in women.Probiotics introduce good bacteria into the vaginal flora, which can help restore normal balance and fight harmful microorganisms.This can lead to reduced symptoms of infection and promote overall vaginal health.
  • Conclusion: In short, probiotics offer a promising approach to the management of bacterial infections of the genital tract in women. Their ability to restore the normal balance of bacteria and support vaginal health makes them a valuable complement to traditional therapies. By choosing the right probiotic strains and including them in a comprehensive treatment plan, women can potentially get rid of these uncomfortable infections.
  • Keywords: Probiotics, Urinary Tract Infections , Lactobacillus , Bacterial Vaginosis