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E-Book 3rd Congress

  • The diagnostic application of nanoparticles for parasitic infections
  • Fatemeh Ataei Masjedlou,1,* Zahra Sobhani,2 Mohammad Taghi Ahady,3
    1. Department of Biology, Ardabil Branch, Islamic Azad University
    2. Department of Biology, Ardabil Branch, Islamic Azad University
    3. Department of Biology, Ardabil Branch, Islamic Azad University


  • Introduction: Introduction: Parasites, including helminths and protozoa, are considered important sources of infections that can endanger public health. Because of this, sensitive, fast, and cost-effective analysis methods are needed to identify these pathogenic agents to achieve a better quality of life. Accurate and quick diagnosis is very important for the prevention and control of parasitic diseases. Several research groups have focused on developing new, efficient, and cost-effective diagnostic techniques. Despite these efforts, diagnostic methods are still not effective due to limitations in terms of cost, sensitivity, specificity, and difficulty of use in this field. According to our topic, nanotechnology offers a new paradigm for various medical diagnostics with unique features. This systematic review aimed to investigate the use of nanoparticles in the diagnosis of parasitic infections.
  • Methods: Methods: In this systematic review, to collect English scientific articles, Google Scholar, Science Direct, NCBI, Springlink, PubMed, and Web of Sciences databases were used, and to collect Persian articles were referred to Magiran, Civilica, Sid, and Google Scholar databases. The keywords used to search for English and Persian articles included nanoparticles, parasite infection, diagnosis, gold nanoparticle, silver nanoparticle, parasite, diagnosis of protozoan parasite, malaria, Trichomonas vaginalis, leishmaniasis, Toxoplasma gondii, and diagnosis via nanoparticle.
  • Results: Results: A total of 83 articles were obtained, of which 15 articles were excluded from this study due to being non-specialized, and a total of 68 articles were selected for writing the present study. During the investigations, it was found that nanoparticles (gold, silver, chitosan, and hydrogel) have been used to detect many parasites. The names of these parasites are as follows: Plasmodium falciparum, Toxoplasma gondii, Cryptosporidium parvum, Cryptosporidium baileyi, Cryptosporidium xiaoi, Cryptosporidium ryanae, Cryptosporidium andersoni, Trichomonas vaginalis, Trichomonas hominis, Trypanosoma cruzi, Echinococcus granulosus, Giardia lamblia, Leishmania infantum, Leishmania donovani, Leishmania major, Leishmania tropica, Entamoeba histolytica, Entamoeba coli, Balantidium coli, Hymenolepis nana, Fasciolopsis buski, Enterobius vermicularis, Ascaris lumbricoides and Leptomonas seymouri. Various methods and techniques have been used for the application of nanoparticles in the detection of parasites, such as conjugation of nanoparticles with probes, conjugation of nanoparticles with strain-specific antibodies, conjugation of nanoparticles with casein, Nano-PCR, ELISA based on nanoparticles, aptasensor based on gold nanoparticles.
  • Conclusion: Conclusion: Based on the results of this study, it is concluded that using nanoparticles to detect parasitic infections is an easy, fast, economical, and sensitive method. It is suggested that the use of nanoparticles in clinical studies be studied more widely.
  • Keywords: Keywords: nanoparticles, parasitic infections, diagnosis, diagnosis of parasitic infections