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E-Book 3rd Congress

  • A review of aptamer-based biosensors for Staphylococcus aureus detection
  • Zahra Ghorbani,1,* Sana Yahyazadeh Jasour,2
    1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
    2. Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran


  • Introduction: Staphylococcus aureus is a gram-positive and spherical bacterium known as one of the most important bacterial pathogens. This bacterium can cause food poisoning and various infectious diseases by producing enterotoxin. This opportunistic and common pathogen in humans can cause a wide range of skin infections to pneumonia and sepsis. Staphylococcus aureus infections are easily transmitted and usually exist in air, water, soil, human skin, etc. Therefore, its rapid identification is critical to treat and prevent the spread of infection.
  • Methods: Many detection methods have been introduced, including bacterial culture with genotype and phenotype detection tests, polymerase chain reaction methods, ligase chain reactions, and enzyme-linked immunosorbent assay. These techniques, despite their high sensitivity, are time-consuming methods and require a lot of facilities and costs. Also, the existence of expert staff and advanced laboratories is essential.
  • Results: Recently, the attention of researchers has been drawn to providing methods with high sensitivity but simple and cheap. Therefore, by using aptamers, new biosensors have been designed that successfully detect Staphylococcus aureus in various samples.
  • Conclusion: In this article, recent studies related to aptamer-based biosensors for the rapid detection of Staphylococcus aureus and the replacement of aptamers with antibodies have been discussed.
  • Keywords: Aptamer, Staphylococcus aureus, biosensor, SELEX