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  • The importance of long non-coding RNAs in prognosis of lymphoma
  • Fatemeh Alipour,1 Amir Atashi,2,* Mansoureh Ajami,3
    1. Student Research Committee of School of Allied Medical Sciences, Shahroud University of Medical Science, Shahroud, Iran
    2. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran
    3. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran


  • Introduction: Lymphomas, leukemias and myelomas are a part of the broader group of cancers of the hematopoietic and lymphoid tissues. Lymphoma is a group of blood and lymph tissue tumors that develop from lymphocytes. The two main categories of lymphomas are the non-Hodgkin lymphoma and Hodgkin lymphoma. Long non-coding RNAs (lncRNAs) are longer than 200 nucleotides and rarely serve as templates for protein synthesis. Several studies have revealed that lncRNAs play important regulatory roles in various life-sustaining processes such as epigenetic regulation, cell cycle control, splicing, and post-transcriptional regulation. Although, the role of lncRNAs in the pathogenesis of the lymphoma has been identified, less has been discussed about its importance in the diagnosis, treatment and especially the prognosis of the lymphoma.
  • Methods: Published articles between 2000 and 2023 examining the role of lncRNAs in prognosis of lymphoma were identified by searching in the PubMed, Scopus and Web of Sciences databases.
  • Results: There is increasing evidence that lncRNAs may also play an important role in the pathogenesis of various cancers, including B-cell malignancies. They can act as scaffolds, guides, ribo‐activators, decoy, competing endogenous RNAs and precursors for small regulatory RNAs. Several studies have used multiple lncRNAs as biomarkers to predict patient prognosis especially in diffuse large B cell lymphoma. It has been proven that six lncRNAs play a role in prognosis of lymphoma (SNHG26, PRKCQ‐AS1, AC018521.5, RPARP‐AS1, AC244090.1 and AC023590.1). Upregulation of SNHG26 and RPARP‐AS1 was associated with poor prognosis. Lower expression of other four lncRNAs was related to poor prognosis. Also, nine lncRNAs with a prominent role in determining patient`s survival have been introduced as lncRNA-regulating epigenetic event signature (ELncSig).
  • Conclusion: Several lncRNAs have a decisive role in lymphoma prognosis, which can be used along with other markers such as cytogenetics and mutation studies to determine patient survival and also to determine the optimal treatment method.
  • Keywords: Long non-coding RNAs (lncRNAs), Lymphoma, prognosis, survival