E-Book

E-Book 3rd Congress

  • Cardiovascular manifestations and role of Endotheliopathy in covid-19 patients
  • Motahare Sadeghi,1,* Younes Sadeghi bojd,2 kiana tavakoli,3 abolfazl miri,4
    1. Student research committee, school of Allied medical science, zahedan university of medical science, zahedan, Iran
    2. Department of Laboratory Sciences, School of Allied Medical Sciences, Zahedan University of Medical Sciences, Zahedan, Iran
    3. Student research committee, school of Allied medical science, zahedan university of medical science, zahedan, Iran
    4. Student research committee, school of Allied medical science, zahedan university of medical science, zahedan, Iran


  • Introduction: SARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is associated with a bewildering array of cardiovascular manifestations, including myocardial infarction and stroke, myocarditis and heart failure, atrial and ventricular arrhythmias, venous thromboembolism, and microvascular disease. Furthermore, the pulmonary infiltration and edema, and later pulmonary fibrosis, in patients with COVID-19 is promoted by endothelial alterations including the expression of endothelial adhesion molecules and chemokines, increased intercellular permeability, and endothelial-to-mesenchyme transitions. Venous thrombosis and pulmonary thromboembolism are most likely associated with an endothelial defect caused by circulating inflammatory cytokines and/or direct endothelial invasion by the virus.
  • Methods: We searched databases including PubMed, Medline, Cochrane, Embase, Scopus and Web of Science databases from 2020 to 2023 and read articles related to the topic.
  • Results: In 29 reviewed articles, 1465 patients were examined, which showed that there were specific changes in biomarkers related to coagulation, the cytokine storm and inflammation.6 .4% of patients with COVID-19 had an elevated troponin I on admission, a hypersensitive marker for cardiac myocyte injury .When these authors looked at acute cardiac injury as an outcome, defined as elevation in troponin I or diagnostic imaging findings, they found a similar 7% overall incidence in patients with COVID-19,but this was increased to 22% among ICU patients(P < .001).
  • Conclusion: A comprehensive characterization of COVID-19–associated endotheliopathy, and an understanding of the mechanisms of acute and chronic endothelial alterations induced by SARS-CoV-2, will lead to an improved understanding of the many manifestations of COVID-19 and a refined management approach for this and other vasculotropic viral diseases. There for immune response induced by the SARS-CoV2 can virus resulted in inflammatory-associated myocarditis and increased oxygen consumption, which disturbed the imbalance of cardiac oxygen supply resulting in plaque rupture and MI.
  • Keywords: COVID-19; SARS-CoV2; endothelium; Heart