E-Book

E-Book 3rd Congress

  • Colorectal cancer vaccine perspective
  • Fatemeh Babaie Dehaghi,1 MohammadSaleh Safari,2 Hossein Rezvan,3,* Sahar HamoonNavard,4
    1. Department of Pathobiology, Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran
    2. Department of Pathobiology, Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran
    3. Department of Pathobiology, Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran
    4. Department of Pathobiology, Faculty of Veterinary Sciences, Bu-Ali Sina University, Hamedan, Iran


  • Introduction: One of the most important causes of death in the world is cancer, and its rate is increasing day by day. Colorectal cancer is the third most common cancer in the world. The main concern about colorectal cancer is that it is difficult to treat or incurable. The treatment methods that have been used so far are chemotherapy, radiotherapy, and removal of a part of the organ. These treatments are effective, but in many cases they cause unwanted side effects. These concerns and problems have led to great progress in the development of colorectal cancer vaccines.
  • Methods: The present study is a review article. By searching the keywords colorectal cancer, vaccine, immunotherapy in PubMed, Scopus, Web of Science databases, 41 articles were found and analyzed.
  • Results: There are different types of these vaccines, which include tumor surface antigens, dendritic cells, cancer cells, etc. All vaccines stimulate the immune system and destroy cancer cells. The manufactured vaccines have little toxicity for the body's natural cells, but they have a great ability to strengthen the immune system. They can also affect proteins in the body that inhibit inflammation. Although these vaccines have proven to be effective, in some cases they have suppressed the immune system. These vaccines are slow acting and the amount of memory cells they produce is low. Recently, the use of adjuvants has been discussed to solve this problem.
  • Conclusion: Colorectal cancer vaccine development started a few decades ago and is still expanding. Its effect in immunogenicity is undeniable, but their use is associated with limitations. Slow immunogenesis in the body and the short period of immunity are among these limitations. The use of vaccines for the prevention and treatment of colorectal cancer requires a detailed understanding of the limitations and further studies to solve them.
  • Keywords: colorectal cancer, vaccine, immunotherapy