E-Book

E-Book 3rd Congress

  • Long Noncoding RNAs (lncRNAs) in Rheumatoid Arthritis Peripheral Blood Mononuclear Cells (PBMCs): A Systematic Review
  • Nazarifard Shadi,1 Rahimi Hadis,2 Ahmadpour Fatemeh,3,* Hormozi Maryam,4
    1. Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
    2. Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
    3. Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
    4. Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


  • Introduction: Rheumatoid arthritis (RA) is a complex autoimmune disorder characterized by inflammation, joint damage, and systemic involvement. This systematic review focuses exclusively on the role of long noncoding RNAs (lncRNAs) in peripheral blood mononuclear cells (PBMCs) of RA patients. We aim to provide a comprehensive analysis of the current literature, emphasizing the potential of PBMC-derived lncRNAs as diagnostic markers and therapeutic targets in RA. Rheumatoid arthritis affects millions worldwide, necessitating a deeper understanding of its molecular mechanisms. Investigating lncRNAs specifically in PBMCs offers insights into the systemic aspects of RA pathology.
  • Methods: A systematic search of databases (PubMed, Scopus, etc.) was conducted to identify studies focusing on lncRNAs in PBMCs of RA patients. Inclusion criteria were applied to select studies exploring lncRNA expression, functions, and clinical relevance. Quality assessment and data extraction were performed.
  • Results: Expression Profiling of PBMC-Derived lncRNAs in RA: An overview of dysregulated lncRNAs in RA PBMCs, such as LINC00304, MIR503HG, LOC100652951, and LOC100506036, provides insights into the specific molecular alterations associated with RA. Functional Roles of PBMC-Derived lncRNAs in RA: Understanding how PBMC-derived lncRNAs contribute to apoptosis, autophagy, and inflammatory responses in RA sheds light on their potential as key regulators in systemic immune dysregulation. Diagnostic Potential of PBMC-Derived lncRNAs in RA: Identification of lncRNAs like MIR22HG, DSCR9, and LINC01189 as potential diagnostic biomarkers, specific to PBMCs, highlights their role in reflecting RA-associated molecular changes systemically. Therapeutic Implications: Exploring the therapeutic potential of targeting dysregulated PBMC-derived lncRNAs, such as LOC100506036, may pave the way for novel interventions aiming at modulating immune responses in RA patients. Challenges and Future Directions: The review discusses challenges in the existing literature, emphasizing the importance of standardized methodologies and the need for larger studies. Recommendations for future research focus on validation and translation to clinical applications.
  • Conclusion: This systematic review emphasizes the unique contribution of PBMC-derived lncRNAs to the understanding of RA pathogenesis. The identified lncRNAs hold promise as diagnostic markers and therapeutic targets, offering avenues for further research in precision medicine for RA.
  • Keywords: Rheumatoid Arthritis, Peripheral Blood Mononuclear Cells (PBMCs),Long Noncoding RNAs (lncRNAs).