E-Book

E-Book 3rd Congress

  • The Calcium-Sensing Receptor in Health and Disease.
  • Alireza Akhavan,1,* Issa Layali,2
    1. Microbiology group, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
    2. Microbiology group, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


  • Introduction: First of all we need to know about Structure and Physiological Functions of calcium-sensing receptor or CaSR. calcium ion (Ca2+) regulates a wide range of intracellular and extracellular processes Follow that thread one of the important organs is Bone. it provides an adequate muscle and nerve function and is required for normal. Because of that is essential for life CaSR most to be to control this important thing.
  • Methods: A. Aggarwal et al. The calcium-sensing receptor: a promising target for prevention of colorectal cancer Biochim. Biophys. Acta (2015) https://www.sciencedirect.com/science/article/pii/S0167488915000518 U. Armato et al. The calcium-sensing receptor: a novel Alzheimer's disease crucial target? J. Neurol. Sci. (2012) https://www.sciencedirect.com/science/article/pii/S0022510X12003656 G. Breitwieser The calcium sensing receptor life cycle: trafficking, cell surface expression, and degradation Best Pract. Res. Clin. Endocrinol. Metab. (2013) https://www.sciencedirect.com/science/article/pii/S0954611103003378 G.E. Breitwieser et al. Calcium sensing receptors as integrators of multiple metabolic signals Cell Calcium (2004) https://www.sciencedirect.com/science/article/pii/S0143416003002185
  • Results: At all we search about CaSR in PTH release in parathyroid glands and calcium homeostasis because it has very good reaction against changes in extracellular Ca2+. However, the CaSR is expressed in numerous tissues and cell types other than parathyroid glands. Accordingly, CaSR may play important physiopathological roles beyond PTH release and extracellular calcium homeostasis . We examine CaSR in several cases 1. CaSR in Endocrine Pathology , 2. CaSR in Cardiovascular Physiopathology , 3. CaSR in Asthma , 4. CaSR in Alzheimer’s Disease , 5. CaSR in Cancer. 1. Given the critical role of the CaSR in the regulation of the entire extracellular Ca2+ homeostatic system, conversion in CaSR signaling pathways are expected to make quite a significant contribution to imbalances of mineral metabolism.CaSR knockout (KO) in mice, CaSR mutations in human, as well as the use of calcimimetics and calcilytics are not just for Calcium and they used in other pathwayes. 2. Another place that CaSR has an effect is in Cardiovascular Physiopathology CaSR is expressed in several cell types in this system including the endothelium, vascular smooth muscle cells (VSMC), and even in the perivascular nerve In the past it was demonstrated that dietary intake of Ca2+ may reduce blood pressure. 3. One of best pre-treatment for asthma do with CaSR . Asthma is characterized by airway hyperresponsiveness, bronchoconstriction, and chronic inflammation. Current treatments for asthma include drugs designed to target not the causes but the symptoms, that is, airway inflammation by corticosteroids and target this part and start treat. 4. AD is a neurodegenerative disorder associated to a progressive and irreversible loss of memoryRecent evidence suggest that CaSR could be a direct target for amyloid β peptides, the most likely toxins in AD 5. Cal causes cell proliferation, differentiation, and cell death predicts a role for this cation in cancer and may may contribute to cancer development. Maybe with CaSR can control cancer and cure this disease
  • Conclusion: So CaSR very useful for cure or treat basical disease and scientist work on these receptor for control calcium in body and cells. we hope to this method make complete soon.
  • Keywords: Keywords: CaSR/calcium/Alzheimer/Asthma/Cancer